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Phosphorylation-induced conformational dynamics in an intrinsically disordered protein and potential role in phenotypic heterogeneity

Intrinsically disordered proteins (IDPs) that lack a unique 3D structure and comprise a large fraction of the human proteome play important roles in numerous cellular functions. Prostate-Associated Gene 4 (PAGE4) is an IDP that acts as a potentiator of the Activator Protein-1 (AP-1) transcription fa...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Kulkarni, Prakash, Jolly, Mohit Kumar, Jia, Dongya, Mooney, Steven M., Bhargava, Ajay, Kagohara, Luciane T., Chen, Yihong, Hao, Pengyu, He, Yanan, Veltri, Robert W., Grishaev, Alexander, Weninger, Keith, Levine, Herbert, Orban, John
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2017
Soggetti:
PNAS Plus
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5380051/
https://ncbi.nlm.nih.gov/pubmed/28289210
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1700082114
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