Ovine multiparity is associated with diminished vaginal muscularis, increased elastic fibres and vaginal wall weakness: implication for pelvic organ prolapse

Pelvic Organ Prolapse (POP) is a major clinical burden affecting 25% of women, with vaginal delivery a major contributing factor. We hypothesised that increasing parity weakens the vagina by altering the extracellular matrix proteins and smooth muscle thereby leading to POP vulnerability. We used a...

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Publicado no:Sci Rep
Main Authors: Emmerson, Stuart, Young, Natharnia, Rosamilia, Anna, Parkinson, Luke, Edwards, Sharon L., Vashi, Aditya V., Davies-Tuck, Miranda, White, Jacinta, Elgass, Kirstin, Lo, Camden, Arkwright, John, Werkmeister, Jerome A., Gargett, Caroline E.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5379562/
https://ncbi.nlm.nih.gov/pubmed/28374826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep45709
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