Inhibition of Cdk5 induces cell death of tumor-initiating cells

BACKGROUND: Tumour-initiating cells (TICs) account for chemoresistance, tumour recurrence and metastasis, and therefore represent a major problem in tumour therapy. However, strategies to address TICs are limited. Recent studies indicate Cdk5 as a promising target for anti-cancer therapy and Cdk5 ha...

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Publicado en:Br J Cancer
Autores principales: Mandl, Melanie M, Zhang, Siwei, Ulrich, Melanie, Schmoeckel, Elisa, Mayr, Doris, Vollmar, Angelika M, Liebl, Johanna
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2017
Materias:
Translational Therapeutics
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5379151/
https://ncbi.nlm.nih.gov/pubmed/28222068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2017.39
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