PHD2 Targeting Overcomes Breast Cancer Cell Death upon Glucose Starvation in a PP2A/B55α-Mediated Manner

B55α is a regulatory subunit of the PP2A phosphatase. We have recently found that B55α-associated PP2A promotes partial deactivation of the HIF-prolyl-hydroxylase enzyme PHD2. Here, we show that, in turn, PHD2 triggers degradation of B55α by hydroxylating it at proline 319. In the context of glucose...

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Vydáno v:Cell Rep
Hlavní autoři: Di Conza, Giusy, Trusso Cafarello, Sarah, Zheng, Xingnan, Zhang, Qing, Mazzone, Massimiliano
Médium: Artigo
Jazyk:Inglês
Vydáno: Cell Press 2017
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5378984/
https://ncbi.nlm.nih.gov/pubmed/28329677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.02.081
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