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Recombinant Soluble Apyrase APT102 Inhibits Thrombosis and Intimal Hyperplasia in Vein Grafts without Adversely Affecting Hemostasis or Re-endothelialization
BACKGROUND: Occlusion of vein grafts (VGs) after bypass surgery due to thrombosis and intimal hyperplasia (IH) is a major clinical problem. Apyrases are enzymes that scavenge extracellular ATP and ADP and promote adenosine formation at sites of vascular injury and hence have potential to inhibit vei...
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| Veröffentlicht in: | J Thromb Haemost |
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| Hauptverfasser: | , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2017
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5378664/ https://ncbi.nlm.nih.gov/pubmed/28079982 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jth.13621 |
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