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Small-molecule RORγt Antagonists: One Stone Kills Two Birds
Although small-molecule RORγt antagonists suppressing Th17 cells are widely reported, the effect of these molecules on other RORγt-expressing cells is unknown. A new study reported that RORγt inhibition in CD4(+)CD8(+) thymocytes resulted in skewed T cell repertoire, contributing to reduction in fre...
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| Publicado no: | Trends Immunol |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5378633/ https://ncbi.nlm.nih.gov/pubmed/28258823 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.it.2017.02.006 |
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