Design, synthesis and evaluation in an LPS rodent model of neuroinflammation of a novel (18)F-labelled PET tracer targeting P2X7

BACKGROUND: The P2X7 receptor has been shown to play a fundamental role in the initiation and sustenance of the inflammatory cascade. The development of a novel fluorine-18 PET tracer superior and with a longer half-life to those currently available is a promising step towards harnessing the therape...

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Bibliographic Details
Published in:EJNMMI Res
Main Authors: Fantoni, Enrico Raffaele, Dal Ben, Diego, Falzoni, Simonetta, Di Virgilio, Francesco, Lovestone, Simon, Gee, Antony
Format: Artigo
Language:Inglês
Published: Springer Berlin Heidelberg 2017
Subjects:
Original Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5378566/
https://ncbi.nlm.nih.gov/pubmed/28374288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13550-017-0275-2
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