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[(18)F]FDG PET signal is driven by astroglial glutamate transport

Contributions of glial cells to neuroenergetics have been the focus of extensive debate. Here we provide the first positron emission tomography (PET) evidence that activation of the astrocytic glutamate transport via GLT-1 triggers widespread but graded glucose uptake in the rodent brain. Our result...

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Detalhes bibliográficos
Publicado no:Nat Neurosci
Main Authors: Zimmer, Eduardo R., Parent, Maxime J., Souza, Débora G., Leuzy, Antoine, Lecrux, Clotilde, Kim, Hyoung-Ihl, Gauthier, Serge, Pellerin, Luc, Hamel, Edith, Rosa-Neto, Pedro
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5378483/
https://ncbi.nlm.nih.gov/pubmed/28135241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.4492
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