Oxidant-induced autophagy and ferritin degradation contribute to epithelial–mesenchymal transition through lysosomal iron

PURPOSE: Transforming growth factor (TGF)-β1 triggers epithelial–mesenchymal transition (EMT) through autophagy, which is partly driven by reactive oxygen species (ROS). The aim of this study was to determine whether leaking lysosomes and enhanced degradation of H-ferritin could be involved in EMT a...

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Détails bibliographiques
Publié dans:J Inflamm Res
Auteurs principaux: Sioutas, Apostolos, Vainikka, Linda K, Kentson, Magnus, Dam-Larsen, Sören, Wennerström, Urban, Jacobson, Petra, Persson, Hans Lennart
Format: Artigo
Langue:Inglês
Publié: Dove Medical Press 2017
Sujets:
Original Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5378460/
https://ncbi.nlm.nih.gov/pubmed/28405169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/JIR.S128292
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