Histone Deacetylase (HDAC) Inhibition Induces IκB Kinase (IKK)-dependent Interleukin-8/CXCL8 Expression in Ovarian Cancer Cells

Overexpression of the pro-angiogenic chemokine IL-8 (CXCL8) is associated with a poor prognosis in several solid tumors, including epithelial ovarian cancer (EOC). Even though histone deacetylase (HDAC) inhibition has shown remarkable antitumor activity in hematological malignancies, it has been les...

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Bibliographische Detailangaben
Veröffentlicht in:J Biol Chem
Hauptverfasser: Gatla, Himavanth R., Zou, Yue, Uddin, Mohammad M., Singha, Bipradeb, Bu, Pengli, Vancura, Ales, Vancurova, Ivana
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2017
Schlagworte:
Molecular Bases of Disease
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5377816/
https://ncbi.nlm.nih.gov/pubmed/28167529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.771014
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