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Decreased Mitochondrial Pyruvate Transport Activity in the Diabetic Heart: ROLE OF MITOCHONDRIAL PYRUVATE CARRIER 2 (MPC2) ACETYLATION

Alterations in mitochondrial function contribute to diabetic cardiomyopathy. We have previously shown that heart mitochondrial proteins are hyperacetylated in OVE26 mice, a transgenic model of type 1 diabetes. However, the universality of this modification and its functional consequences are not wel...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Vadvalkar, Shraddha S., Matsuzaki, Satoshi, Eyster, Craig A., Giorgione, Jennifer R., Bockus, Lee B., Kinter, Caroline S., Kinter, Michael, Humphries, Kenneth M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5377762/
https://ncbi.nlm.nih.gov/pubmed/28154187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.753509
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