Small GTPase Rab8a-recruited Phosphatidylinositol 3-Kinase γ Regulates Signaling and Cytokine Outputs from Endosomal Toll-like Receptors

LPS-mediated activation of Toll-like receptor 4 (TLR4) in macrophages results in the coordinated release of proinflammatory cytokines, followed by regulatory mediators, to ensure that this potentially destructive pathway is tightly regulated. We showed previously that Rab8a recruits PI3Kγ for Akt-de...

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書目詳細資料
發表在:J Biol Chem
Main Authors: Wall, Adam A., Luo, Lin, Hung, Yu, Tong, Samuel J., Condon, Nicholas D., Blumenthal, Antje, Sweet, Matthew J., Stow, Jennifer L.
格式: Artigo
語言:Inglês
出版: American Society for Biochemistry and Molecular Biology 2017
主題:
Cell Biology
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5377761/
https://ncbi.nlm.nih.gov/pubmed/28130450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.766337
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