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Fundamental mechanisms of telomerase action in yeasts and mammals: understanding telomeres and telomerase in cancer cells

Aberrant activation of telomerase occurs in 85–90% of all cancers and underpins the ability of cancer cells to bypass their proliferative limit, rendering them immortal. The activity of telomerase is tightly controlled at multiple levels, from transcriptional regulation of the telomerase components...

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Bibliografski detalji
Izdano u:Open Biol
Glavni autori: Armstrong, Christine A., Tomita, Kazunori
Format: Artigo
Jezik:Inglês
Izdano: The Royal Society 2017
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5376709/
https://ncbi.nlm.nih.gov/pubmed/28330934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rsob.160338
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