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Long-acting protein drugs for the treatment of ocular diseases

Protein drugs that neutralize vascular endothelial growth factor (VEGF), such as aflibercept or ranibizumab, rescue vision in patients with retinal vascular diseases. Nonetheless, optimal visual outcomes require intraocular injections as frequently as every month. Here we report a method to extend t...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Ghosh, Joy G., Nguyen, Andrew A., Bigelow, Chad E., Poor, Stephen, Qiu, Yubin, Rangaswamy, Nalini, Ornberg, Richard, Jackson, Brittany, Mak, Howard, Ezell, Tucker, Kenanova, Vania, de la Cruz, Elisa, Carrion, Ana, Etemad-Gilbertson, Bijan, Caro, Roxana Garcia, Zhu, Kan, George, Vinney, Bai, Jirong, Sharma-Nahar, Radhika, Shen, Siyuan, Wang, Yiqin, Subramanian, Kulandayan K., Fassbender, Elizabeth, Maker, Michael, Hanks, Shawn, Vrouvlianis, Joanna, Leehy, Barrett, Long, Debby, Prentiss, Melissa, Kansara, Viral, Jaffee, Bruce, Dryja, Thaddeus P., Roguska, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5376645/
https://ncbi.nlm.nih.gov/pubmed/28332616
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms14837
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