Effects of Mutations on the Aggregation Propensity of the Human Prion-Like Protein hnRNPA2B1

Hundreds of human proteins contain prion-like domains, which are a subset of low-complexity domains with high amino acid compositional similarity to yeast prion domains. A recently characterized mutation in the prion-like domain of the human heterogeneous nuclear ribonucleoprotein hnRNPA2B1 increase...

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Udgivet i:Mol Cell Biol
Main Authors: Paul, Kacy R., Molliex, Amandine, Cascarina, Sean, Boncella, Amy E., Taylor, J. Paul, Ross, Eric D.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2017
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5376634/
https://ncbi.nlm.nih.gov/pubmed/28137911
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00652-16
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