PCGF6-PRC1 suppresses premature differentiation of mouse embryonic stem cells by regulating germ cell-related genes

The ring finger protein PCGF6 (polycomb group ring finger 6) interacts with RING1A/B and E2F6 associated factors to form a non-canonical PRC1 (polycomb repressive complex 1) known as PCGF6-PRC1. Here, we demonstrate that PCGF6-PRC1 plays a role in repressing a subset of PRC1 target genes by recruiti...

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Vydáno v:eLife
Hlavní autoři: Endoh, Mitsuhiro, Endo, Takaho A, Shinga, Jun, Hayashi, Katsuhiko, Farcas, Anca, Ma, Kit-Wan, Ito, Shinsuke, Sharif, Jafar, Endoh, Tamie, Onaga, Naoko, Nakayama, Manabu, Ishikura, Tomoyuki, Masui, Osamu, Kessler, Benedikt M, Suda, Toshio, Ohara, Osamu, Okuda, Akihiko, Klose, Robert, Koseki, Haruhiko
Médium: Artigo
Jazyk:Inglês
Vydáno: eLife Sciences Publications, Ltd 2017
Témata:
Cell Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5375644/
https://ncbi.nlm.nih.gov/pubmed/28304275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.21064
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