Murine systemic thrombophilia and hemolytic uremic syndrome from a factor H point mutation

Complement plays a key role in host defense, but its dysregulation can cause autologous tissue injury. Complement activation is normally controlled by regulatory proteins, including factor H (FH) in plasma and membrane cofactor protein (MCP) on the cell surface. Mutations in FH and MCP are linked to...

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Veröffentlicht in:Blood
Hauptverfasser: Ueda, Yoshiyasu, Mohammed, Imran, Song, Delu, Gullipalli, Damodar, Zhou, Lin, Sato, Sayaka, Wang, Yuan, Gupta, Shuchi, Cheng, Zhongjian, Wang, Hong, Bao, Jialing, Mao, Yingying, Brass, Lawrence, Zheng, X. Long, Miwa, Takashi, Palmer, Matthew, Dunaief, Joshua, Song, Wen-Chao
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2017
Schlagworte:
Platelets and Thrombopoiesis
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5374733/
https://ncbi.nlm.nih.gov/pubmed/28057640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2016-07-728253
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