Cerebrospinal fluid cell-free mitochondrial DNA is associated with HIV replication, iron transport, and mild HIV-associated neurocognitive impairment

BACKGROUND: Mitochondria are abundant organelles critical for energy metabolism and brain function. Mitochondrial DNA (mtDNA), released during cellular injury and as part of the innate immune response to viral pathogens, contains CpG motifs that act as TLR-9 ligands. We investigated relationships be...

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Bibliographic Details
Published in:J Neuroinflammation
Main Authors: Mehta, Sanjay R., Pérez-Santiago, Josué, Hulgan, Todd, Day, Tyler R. C., Barnholtz-Sloan, Jill, Gittleman, Haley, Letendre, Scott, Ellis, Ronald, Heaton, Robert, Patton, Stephanie, Suben, Jesse D., Franklin, Donald, Rosario, Debralee, Clifford, David B., Collier, Ann C., Marra, Christina M., Gelman, Benjamin B., McArthur, Justin, McCutchan, Allen, Morgello, Susan, Simpson, David, Connor, James, Grant, Igor, Kallianpur, Asha
Format: Artigo
Language:Inglês
Published: BioMed Central 2017
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5374652/
https://ncbi.nlm.nih.gov/pubmed/28359324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-017-0848-z
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