Cerebrospinal fluid cell-free mitochondrial DNA is associated with HIV replication, iron transport, and mild HIV-associated neurocognitive impairment

BACKGROUND: Mitochondria are abundant organelles critical for energy metabolism and brain function. Mitochondrial DNA (mtDNA), released during cellular injury and as part of the innate immune response to viral pathogens, contains CpG motifs that act as TLR-9 ligands. We investigated relationships be...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:J Neuroinflammation
Κύριοι συγγραφείς: Mehta, Sanjay R., Pérez-Santiago, Josué, Hulgan, Todd, Day, Tyler R. C., Barnholtz-Sloan, Jill, Gittleman, Haley, Letendre, Scott, Ellis, Ronald, Heaton, Robert, Patton, Stephanie, Suben, Jesse D., Franklin, Donald, Rosario, Debralee, Clifford, David B., Collier, Ann C., Marra, Christina M., Gelman, Benjamin B., McArthur, Justin, McCutchan, Allen, Morgello, Susan, Simpson, David, Connor, James, Grant, Igor, Kallianpur, Asha
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: BioMed Central 2017
Θέματα:
Research
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5374652/
https://ncbi.nlm.nih.gov/pubmed/28359324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-017-0848-z
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