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Improving the accuracy of high-throughput protein-protein affinity prediction may require better training data

BACKGROUND: One goal of structural biology is to understand how a protein’s 3-dimensional conformation determines its capacity to interact with potential ligands. In the case of small chemical ligands, deconstructing a static protein-ligand complex into its constituent atom-atom interactions is typi...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:BMC Bioinformatics
Egile Nagusiak: Dias, Raquel, Kolaczkowski, Bryan
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: BioMed Central 2017
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5374557/
https://ncbi.nlm.nih.gov/pubmed/28361672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12859-017-1533-z
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