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Identification of a Potent Allosteric Inhibitor of Human Protein Kinase CK2 by Bacterial Surface Display Library Screening

Human protein kinase CK2 has emerged as promising target for the treatment of neoplastic diseases. The vast majority of kinase inhibitors known today target the ATP binding site, which is highly conserved among kinases and hence leads to limited selectivity. In order to identify non-ATP competitive...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Pharmaceuticals (Basel)
Main Authors: Nienberg, Christian, Garmann, Claudia, Gratz, Andreas, Bollacke, Andre, Götz, Claudia, Jose, Joachim
פורמט: Artigo
שפה:Inglês
יצא לאור: MDPI 2017
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC5374410/
https://ncbi.nlm.nih.gov/pubmed/28067769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ph10010006
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