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Long-term follow-up of a randomized AAV2-GAD gene therapy trial for Parkinson’s disease

BACKGROUND. We report the 12-month clinical and imaging data on the effects of bilateral delivery of the glutamic acid decarboxylase gene into the subthalamic nuclei (STN) of advanced Parkinson’s disease (PD) patients. METHODS. 45 PD patients were enrolled in a 6-month double-blind randomized trial...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Niethammer, Martin, Tang, Chris C., LeWitt, Peter A., Rezai, Ali R., Leehey, Maureen A., Ojemann, Steven G., Flaherty, Alice W., Eskandar, Emad N., Kostyk, Sandra K., Sarkar, Atom, Siddiqui, Mustafa S., Tatter, Stephen B., Schwalb, Jason M., Poston, Kathleen L., Henderson, Jaimie M., Kurlan, Roger M., Richard, Irene H., Sapan, Christine V., Eidelberg, David, During, Matthew J., Kaplitt, Michael G., Feigin, Andrew
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5374069/
https://ncbi.nlm.nih.gov/pubmed/28405611
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.90133
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