Mesothelin/mucin 16 signaling in activated portal fibroblasts regulates cholestatic liver fibrosis

Cholestatic liver fibrosis is caused by obstruction of the biliary tract and is associated with early activation of portal fibroblasts (PFs) that express Thy-1, fibulin 2, and the recently identified marker mesothelin (MSLN). Here, we have demonstrated that activated PFs (aPFs) and myofibroblasts pl...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Koyama, Yukinori, Wang, Ping, Liang, Shuang, Iwaisako, Keiko, Liu, Xiao, Xu, Jun, Zhang, Mingjun, Sun, Mengxi, Cong, Min, Karin, Daniel, Taura, Kojiro, Benner, Chris, Heinz, Sven, Bera, Tapan, Brenner, David A., Kisseleva, Tatiana
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5373891/
https://ncbi.nlm.nih.gov/pubmed/28287406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI88845
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