Mesothelin/mucin 16 signaling in activated portal fibroblasts regulates cholestatic liver fibrosis

Cholestatic liver fibrosis is caused by obstruction of the biliary tract and is associated with early activation of portal fibroblasts (PFs) that express Thy-1, fibulin 2, and the recently identified marker mesothelin (MSLN). Here, we have demonstrated that activated PFs (aPFs) and myofibroblasts pl...

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Dades bibliogràfiques
Publicat a:J Clin Invest
Autors principals: Koyama, Yukinori, Wang, Ping, Liang, Shuang, Iwaisako, Keiko, Liu, Xiao, Xu, Jun, Zhang, Mingjun, Sun, Mengxi, Cong, Min, Karin, Daniel, Taura, Kojiro, Benner, Chris, Heinz, Sven, Bera, Tapan, Brenner, David A., Kisseleva, Tatiana
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2017
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5373891/
https://ncbi.nlm.nih.gov/pubmed/28287406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI88845
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