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Differential clinical pharmacology of rolapitant in delayed chemotherapy-induced nausea and vomiting (CINV)

Rolapitant is a highly selective neurokinin-1 receptor antagonist, orally administered for a single dose of 180 mg before chemotherapy with granisetron D1, dexamethasone 8 mg BID on day 2–4. It has a unique pharmacological characteristic of a long plasma half-life (between 163 and 183 hours); this l...

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Bibliografiske detaljer
Udgivet i:Drug Des Devel Ther
Main Authors: Rashad, Noha, Abdel-Rahman, Omar
Format: Artigo
Sprog:Inglês
Udgivet: Dove Medical Press 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5373840/
https://ncbi.nlm.nih.gov/pubmed/28392676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S108872
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