Persistent gating deficit and increased sensitivity to NMDA receptor antagonism after puberty in a new mouse model of the human 22q11.2 microdeletion syndrome: a study in male mice

BACKGROUND: The hemizygous 22q11.2 microdeletion is a common copy number variant in humans. The deletion confers high risk for neurodevelopmental disorders, including autism and schizophrenia. Up to 41% of deletion carriers experience psychotic symptoms. METHODS: We present a new mouse model (Df(h22...

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Veröffentlicht in:J Psychiatry Neurosci
Hauptverfasser: Didriksen, Michael, Fejgin, Kim, Nilsson, Simon R.O., Birknow, Michelle R., Grayton, Hannah M., Larsen, Peter H., Lauridsen, Jes B., Nielsen, Vibeke, Celada, Pau, Santana, Noemi, Kallunki, Pekka, Christensen, Kenneth V., Werge, Thomas M., Stensbøl, Tine B., Egebjerg, Jan, Gastambide, Francois, Artigas, Francesc, Bastlund, Jesper F., Nielsen, Jacob
Format: Artigo
Sprache:Inglês
Veröffentlicht: Joule Inc. 2017
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5373712/
https://ncbi.nlm.nih.gov/pubmed/27391101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1503/jpn.150381
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