Persistent gating deficit and increased sensitivity to NMDA receptor antagonism after puberty in a new mouse model of the human 22q11.2 microdeletion syndrome: a study in male mice

BACKGROUND: The hemizygous 22q11.2 microdeletion is a common copy number variant in humans. The deletion confers high risk for neurodevelopmental disorders, including autism and schizophrenia. Up to 41% of deletion carriers experience psychotic symptoms. METHODS: We present a new mouse model (Df(h22...

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Detalhes bibliográficos
Publicado no:J Psychiatry Neurosci
Main Authors: Didriksen, Michael, Fejgin, Kim, Nilsson, Simon R.O., Birknow, Michelle R., Grayton, Hannah M., Larsen, Peter H., Lauridsen, Jes B., Nielsen, Vibeke, Celada, Pau, Santana, Noemi, Kallunki, Pekka, Christensen, Kenneth V., Werge, Thomas M., Stensbøl, Tine B., Egebjerg, Jan, Gastambide, Francois, Artigas, Francesc, Bastlund, Jesper F., Nielsen, Jacob
Formato: Artigo
Idioma:Inglês
Publicado em: Joule Inc. 2017
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Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5373712/
https://ncbi.nlm.nih.gov/pubmed/27391101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1503/jpn.150381
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