Persistent gating deficit and increased sensitivity to NMDA receptor antagonism after puberty in a new mouse model of the human 22q11.2 microdeletion syndrome: a study in male mice

BACKGROUND: The hemizygous 22q11.2 microdeletion is a common copy number variant in humans. The deletion confers high risk for neurodevelopmental disorders, including autism and schizophrenia. Up to 41% of deletion carriers experience psychotic symptoms. METHODS: We present a new mouse model (Df(h22...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Psychiatry Neurosci
Prif Awduron: Didriksen, Michael, Fejgin, Kim, Nilsson, Simon R.O., Birknow, Michelle R., Grayton, Hannah M., Larsen, Peter H., Lauridsen, Jes B., Nielsen, Vibeke, Celada, Pau, Santana, Noemi, Kallunki, Pekka, Christensen, Kenneth V., Werge, Thomas M., Stensbøl, Tine B., Egebjerg, Jan, Gastambide, Francois, Artigas, Francesc, Bastlund, Jesper F., Nielsen, Jacob
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Joule Inc. 2017
Pynciau:
Research Paper
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5373712/
https://ncbi.nlm.nih.gov/pubmed/27391101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1503/jpn.150381
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