APOL1–Mediated Cell Injury Involves Disruption of Conserved Trafficking Processes

APOL1 harbors C–terminal sequence variants (G1 and G2), which account for much of the increased risk for kidney disease in sub–Saharan African ancestry populations. Expression of the risk variants has also been shown to cause injury to podocytes and other cell types, but the underlying mechanisms ar...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:J Am Soc Nephrol
Autori principali: Kruzel-Davila, Etty, Shemer, Revital, Ofir, Ayala, Bavli-Kertselli, Ira, Darlyuk-Saadon, Ilona, Oren-Giladi, Pazit, Wasser, Walter G., Magen, Daniella, Zaknoun, Eid, Schuldiner, Maya, Salzberg, Adi, Kornitzer, Daniel, Marelja, Zvonimir, Simons, Matias, Skorecki, Karl
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Nephrology 2017
Soggetti:
Basic Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5373454/
https://ncbi.nlm.nih.gov/pubmed/27864431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2016050546
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