Inhibition of L-Type Ca(2+) Channels by TRPC1-STIM1 Complex Is Essential for the Protection of Dopaminergic Neurons

Loss of dopaminergic (DA) neurons leads to Parkinson's disease; however, the mechanism(s) for the vulnerability of DA neurons is(are) not fully understood. We demonstrate that TRPC1 regulates the L-type Ca(2+) channel that contributes to the rhythmic activity of adult DA neurons in the substant...

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Publicado en:J Neurosci
Autores principales: Sun, Yuyang, Zhang, Haopeng, Selvaraj, Senthil, Sukumaran, Pramod, Lei, Saobo, Birnbaumer, Lutz, Singh, Brij B.
Formato: Artigo
Lenguaje:Inglês
Publicado: Society for Neuroscience 2017
Materias:
Research Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5373123/
https://ncbi.nlm.nih.gov/pubmed/28258168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3010-16.2017
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