Argininosuccinate Synthase 1-Deficiency Enhances the Cell Sensitivity to Arginine through Decreased DEPTOR Expression in Endometrial Cancer

Argininosuccinate synthetase 1 (ASS1) is a rate-limiting enzyme in arginine biosynthesis. Although ASS1 expression levels are often reduced in several tumors and low ASS1 expression can be a poor prognostic factor, the underlying mechanism has not been elucidated. In this study, we reveal a novel as...

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Published in:Sci Rep
Main Authors: Ohshima, Kenji, Nojima, Satoshi, Tahara, Shinichiro, Kurashige, Masako, Hori, Yumiko, Hagiwara, Kohei, Okuzaki, Daisuke, Oki, Shinya, Wada, Naoki, Ikeda, Jun-ichiro, Kanai, Yoshikatsu, Morii, Eiichi
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5371991/
https://ncbi.nlm.nih.gov/pubmed/28358054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep45504
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