Clinical Features, Etiology, and Outcomes of Community-Acquired Pneumonia in Patients With Diabetes Mellitus

We performed an observational analysis of a prospective cohort of immunocompetent hospitalized adults with community-acquired pneumonia (CAP) to determine the epidemiology, clinical features, and outcomes of pneumonia in patients with diabetes mellitus (DM). We also analyzed the risk factors for mor...

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Published in:Medicine (Baltimore)
Main Authors: Di Yacovo, Silvana, Garcia-Vidal, Carolina, Viasus, Diego, Adamuz, Jordi, Oriol, Isabel, Gili, Francesca, Vilarrasa, Núria, García-Somoza, M. Dolors, Dorca, Jordi, Carratalà, Jordi
Format: Artigo
Language:Inglês
Published: Wolters Kluwer Health 2013
Subjects:
Observational Study
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5370750/
https://ncbi.nlm.nih.gov/pubmed/23263718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/MD.0b013e31827f602a
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spelling pubmed-53707502017-04-03 Clinical Features, Etiology, and Outcomes of Community-Acquired Pneumonia in Patients With Diabetes Mellitus Di Yacovo, Silvana Garcia-Vidal, Carolina Viasus, Diego Adamuz, Jordi Oriol, Isabel Gili, Francesca Vilarrasa, Núria García-Somoza, M. Dolors Dorca, Jordi Carratalà, Jordi Medicine (Baltimore) Observational Study We performed an observational analysis of a prospective cohort of immunocompetent hospitalized adults with community-acquired pneumonia (CAP) to determine the epidemiology, clinical features, and outcomes of pneumonia in patients with diabetes mellitus (DM). We also analyzed the risk factors for mortality and the impact of statins and other cardiovascular drugs on outcomes. Of 2407 CAP episodes, 516 (21.4%) occurred in patients with DM; 483 (97%) had type 2 diabetes, 197 (40%) were on insulin treatment, and 119 (23.9%) had end-organ damage related to DM. Patients with DM had different clinical features compared to the other patients. They were less likely to have acute onset, cough, purulent sputum, and pleural chest pain. No differences in etiology were found between study groups. Patients with DM had more inhospital acute metabolic complications, although the case-fatality rate was similar between the groups. Independent risk factors for mortality in patients with DM were advanced age, bacteremia, septic shock, and gram-negative pneumonia. Patients with end-organ damage related to DM had more inhospital cardiac events and a higher early case-fatality rate than did the overall population. The use of statins and other cardiovascular drugs was not associated with better CAP outcomes in patients with DM. In conclusion, CAP in patients with DM presents different clinical features compared to the features of patients without DM. Wolters Kluwer Health 2013-01-01 /pmc/articles/PMC5370750/ /pubmed/23263718 http://dx.doi.org/10.1097/MD.0b013e31827f602a Text en Copyright © 2013 by Lippincott Williams & Wilkins
institution US NLM
collection PubMed Central
language Inglês
format Artigo
topic Observational Study
spellingShingle Observational Study
Di Yacovo, Silvana
Garcia-Vidal, Carolina
Viasus, Diego
Adamuz, Jordi
Oriol, Isabel
Gili, Francesca
Vilarrasa, Núria
García-Somoza, M. Dolors
Dorca, Jordi
Carratalà, Jordi
Clinical Features, Etiology, and Outcomes of Community-Acquired Pneumonia in Patients With Diabetes Mellitus
description We performed an observational analysis of a prospective cohort of immunocompetent hospitalized adults with community-acquired pneumonia (CAP) to determine the epidemiology, clinical features, and outcomes of pneumonia in patients with diabetes mellitus (DM). We also analyzed the risk factors for mortality and the impact of statins and other cardiovascular drugs on outcomes. Of 2407 CAP episodes, 516 (21.4%) occurred in patients with DM; 483 (97%) had type 2 diabetes, 197 (40%) were on insulin treatment, and 119 (23.9%) had end-organ damage related to DM. Patients with DM had different clinical features compared to the other patients. They were less likely to have acute onset, cough, purulent sputum, and pleural chest pain. No differences in etiology were found between study groups. Patients with DM had more inhospital acute metabolic complications, although the case-fatality rate was similar between the groups. Independent risk factors for mortality in patients with DM were advanced age, bacteremia, septic shock, and gram-negative pneumonia. Patients with end-organ damage related to DM had more inhospital cardiac events and a higher early case-fatality rate than did the overall population. The use of statins and other cardiovascular drugs was not associated with better CAP outcomes in patients with DM. In conclusion, CAP in patients with DM presents different clinical features compared to the features of patients without DM.
author Di Yacovo, Silvana
Garcia-Vidal, Carolina
Viasus, Diego
Adamuz, Jordi
Oriol, Isabel
Gili, Francesca
Vilarrasa, Núria
García-Somoza, M. Dolors
Dorca, Jordi
Carratalà, Jordi
author_facet Di Yacovo, Silvana
Garcia-Vidal, Carolina
Viasus, Diego
Adamuz, Jordi
Oriol, Isabel
Gili, Francesca
Vilarrasa, Núria
García-Somoza, M. Dolors
Dorca, Jordi
Carratalà, Jordi
author_sort Di Yacovo, Silvana
title Clinical Features, Etiology, and Outcomes of Community-Acquired Pneumonia in Patients With Diabetes Mellitus
title_short Clinical Features, Etiology, and Outcomes of Community-Acquired Pneumonia in Patients With Diabetes Mellitus
title_full Clinical Features, Etiology, and Outcomes of Community-Acquired Pneumonia in Patients With Diabetes Mellitus
title_fullStr Clinical Features, Etiology, and Outcomes of Community-Acquired Pneumonia in Patients With Diabetes Mellitus
title_full_unstemmed Clinical Features, Etiology, and Outcomes of Community-Acquired Pneumonia in Patients With Diabetes Mellitus
title_sort clinical features, etiology, and outcomes of community-acquired pneumonia in patients with diabetes mellitus
publisher Wolters Kluwer Health
container_title Medicine (Baltimore)
publishDate 2013
url https://ncbi.nlm.nih.gov/pmc/articles/PMC5370750/
https://ncbi.nlm.nih.gov/pubmed/23263718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/MD.0b013e31827f602a
_version_ 1819024599583555584

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