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Reconciling the understanding of ‘hydrophobicity’ with physics-based models of proteins

The idea that a ‘hydrophobic energy’ drives protein folding, aggregation, and binding by favoring the sequestration of bulky residues from water into the protein interior is widespread. The solvation free energies (∆G(solv)) of small nonpolar solutes increase with surface area (A), and the free ener...

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Detalhes bibliográficos
Publicado no:J Phys Condens Matter
Main Authors: Harris, Robert C, Pettitt, B Montgomery
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5370576/
https://ncbi.nlm.nih.gov/pubmed/26836518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1088/0953-8984/28/8/083003
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