Expression of recombinant glutathione S-transferase pi, Ya, or Yb1 confers resistance to alkylating agents.
Increased levels of glutathione S-transferase (GST; RX:glutathione R-transferase; EC 2.5.1.18) mRNA, protein, and activity in tumor biopsy samples and in drug-resistant cultured cells are associated with resistance to anticancer drugs. We report that each of three full-length cloned GST cDNAs, that...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1990
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC53705/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2320566/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.87.7.2443 |
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