Chlamydia trachomatis-containing vacuole serves as deubiquitination platform to stabilize Mcl-1 and to interfere with host defense

Obligate intracellular Chlamydia trachomatis replicate in a membrane-bound vacuole called inclusion, which serves as a signaling interface with the host cell. Here, we show that the chlamydial deubiquitinating enzyme (Cdu) 1 localizes in the inclusion membrane and faces the cytosol with the active d...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Fischer, Annette, Harrison, Kelly S, Ramirez, Yesid, Auer, Daniela, Chowdhury, Suvagata Roy, Prusty, Bhupesh K, Sauer, Florian, Dimond, Zoe, Kisker, Caroline, Hefty, P Scott, Rudel, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2017
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5370187/
https://ncbi.nlm.nih.gov/pubmed/28347402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.21465
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