Lack of IL-1R8 in neurons causes hyperactivation of IL-1 receptor pathway and induces MECP2-dependent synaptic defects

Inflammation modifies risk and/or severity of a variety of brain diseases through still elusive molecular mechanisms. Here we show that hyperactivation of the interleukin 1 pathway, through either ablation of the interleukin 1 receptor 8 (IL-1R8, also known as SIGIRR or Tir8) or activation of IL-1R,...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Tomasoni, Romana, Morini, Raffaella, Lopez-Atalaya, Jose P, Corradini, Irene, Canzi, Alice, Rasile, Marco, Mantovani, Cristina, Pozzi, Davide, Garlanda, Cecilia, Mantovani, Alberto, Menna, Elisabetta, Barco, Angel, Matteoli, Michela
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2017
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5370184/
https://ncbi.nlm.nih.gov/pubmed/28347403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.21735
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