Reduction of oxidative-nitrosative stress underlies anticataract effect of topically applied tocotrienol in streptozotocin-induced diabetic rats

Cataract, a leading cause of blindness, is of special concern in diabetics as it occurs at earlier onset. Polyol accumulation and increased oxidative-nitrosative stress in cataractogenesis are associated with NFκB activation, iNOS expression, ATP depletion, loss of ATPase functions, calpain activati...

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Veröffentlicht in:PLoS One
Hauptverfasser: Abdul Nasir, Nurul Alimah, Agarwal, Renu, Sheikh Abdul Kadir, Siti Hamimah, Vasudevan, Sushil, Tripathy, Minaketan, Iezhitsa, Igor, Mohammad Daher, Aqil, Ibrahim, Mohd Ikraam, Mohd Ismail, Nafeeza
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2017
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5370128/
https://ncbi.nlm.nih.gov/pubmed/28350848
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0174542
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