An open label phase II study evaluating first-line EGFR tyrosine kinase inhibitor erlotinib in non-small cell lung cancer patients with tumors showing high EGFR gene copy number

BACKGROUND: First-line treatment with epidermal growth factor receptor (EGFR) inhibitors in NSCLC is effective in patients with activating EGFR mutations. The activity of erlotinib in patients harboring high EGFR gene copy number has been considered debatable. PATIENTS AND METHODS: A multicenter, op...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Szutowicz-Zielinska, Ewa, Konopa, Krzysztof, Kowalczyk, Anna, Suszko-Kazarnowicz, Malgorzata, Duchnowska, Renata, Szczesna, Aleksandra, Ratajska, Magdalena, Sowa, Aleksander, Limon, Janusz, Biernat, Wojciech, Burzykowski, Tomasz, Jassem, Jacek, Dziadziuszko, Rafal
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Clinical Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5370039/
https://ncbi.nlm.nih.gov/pubmed/27924059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.13793
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