Activation of PI3K in response to high glucose leads to regulation of SOCS-3 and STAT1/3 signals and induction of glomerular mesangial extracellular matrix formation

Excessive deposition of extracellular matrix (ECM) in the glomerulus contributed by mesangial cells is the hallmark of diabetic nephropathy, eventually leading to glomerulosclerosis. In this study, we examined the regulatory signals involved in the high glucose (HG)-induced overproduction of ECM in...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Sheu, Meei-Ling, Shen, Chin-Chang, Jheng, Jia-Rong, Chiang, Chih-Kang
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5370011/
https://ncbi.nlm.nih.gov/pubmed/28129651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.14808
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