A screen for Fli-1 transcriptional modulators identifies PKC agonists that induce erythroid to megakaryocytic differentiation and suppress leukemogenesis

The ETS-related transcription factor Fli-1 affects many developmental programs including erythroid and megakaryocytic differentiation, and is frequently de-regulated in cancer. Fli-1 was initially isolated following retrovirus insertional mutagenesis screens for leukemic initiator genes, and accordi...

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Veröffentlicht in:Oncotarget
Hauptverfasser: Liu, Tangjingjun, Yao, Yao, Zhang, Gang, Wang, Ye, Deng, Bin, Song, Jialei, Li, Xiaogang, Han, Fei, Xiao, Xiao, Yang, Jue, Xia, Lei, Li, You-Jun, Plachynta, Maksym, Zhang, Mu, Yan, Chen, Mu, Shuzhen, Luo, Heng, Zacksenhaus, Eldad, Hao, Xiaojiang, Ben-David, Yaacov
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2016
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5369997/
https://ncbi.nlm.nih.gov/pubmed/28052010
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.14377
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