Molecular phenotyping of multiple mouse strains under metabolic challenge uncovers a role for Elovl2 in glucose-induced insulin secretion

OBJECTIVE: In type 2 diabetes (T2D), pancreatic β cells become progressively dysfunctional, leading to a decline in insulin secretion over time. In this study, we aimed to identify key genes involved in pancreatic beta cell dysfunction by analyzing multiple mouse strains in parallel under metabolic...

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Udgivet i:Mol Metab
Main Authors: Cruciani-Guglielmacci, Céline, Bellini, Lara, Denom, Jessica, Oshima, Masaya, Fernandez, Neïké, Normandie-Levi, Priscilla, Berney, Xavier P., Kassis, Nadim, Rouch, Claude, Dairou, Julien, Gorman, Tracy, Smith, David M., Marley, Anna, Liechti, Robin, Kuznetsov, Dmitry, Wigger, Leonore, Burdet, Frédéric, Lefèvre, Anne-Laure, Wehrle, Isabelle, Uphues, Ingo, Hildebrandt, Tobias, Rust, Werner, Bernard, Catherine, Ktorza, Alain, Rutter, Guy A., Scharfmann, Raphael, Xenarios, Ioannis, Le Stunff, Hervé, Thorens, Bernard, Magnan, Christophe, Ibberson, Mark
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2017
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Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5369210/
https://ncbi.nlm.nih.gov/pubmed/28377873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2017.01.009
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