Development and validation of a high-throughput calcium mobilization assay for the orphan receptor GPR88

BACKGROUND: GPR88 is an orphan G protein-coupled receptor highly expressed in the striatum and is implicated in basal ganglia-associated disorders. However, the receptor functions of GPR88 are still largely unknown due to the lack of potent and selective ligands appropriate for central nervous syste...

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Detalhes bibliográficos
Publicado no:J Biomed Sci
Main Authors: Decker, Ann M., Gay, Elaine A., Mathews, Kelly M., Rosa, Taylor C., Langston, Tiffany L., Maitra, Rangan, Jin, Chunyang
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2017
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5369193/
https://ncbi.nlm.nih.gov/pubmed/28347302
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12929-017-0330-3
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