Paroxetine alleviates T lymphocyte activation and infiltration to joints of collagen-induced arthritis

T cell infiltration to synovial tissue is an early pathogenic mechanism of rheumatoid arthritis (RA). In the present work, we reveal that G protein coupled receptor kinase 2 (GRK2) is abundantly expressed in T cells of collagen-induced arthritis (CIA). A GRK2 inhibitor, paroxetine protects the joint...

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Udgivet i:Sci Rep
Main Authors: Wang, Qingtong, Wang, Longsheng, Wu, Li, Zhang, Mei, Hu, Shanshan, Wang, Rui, Han, Yongsheng, Wu, Yujing, Zhang, Lingling, Wang, Xinming, Sun, Wuyi, Wei, Wei
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5368980/
https://ncbi.nlm.nih.gov/pubmed/28349925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep45364
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