Artonin E induces p53-independent G1 cell cycle arrest and apoptosis through ROS-mediated mitochondrial pathway and livin suppression in MCF-7 cells

Artonin E is a prenylated flavonoid compound isolated from the stem bark of Artocarpus elasticus. This phytochemical has been previously reported to be drug-like with full compliance to Lipinski’s rule of five and good physicochemical properties when compared with 95% of orally available drugs. It h...

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Detalhes bibliográficos
Publicado no:Drug Des Devel Ther
Main Authors: Etti, Imaobong Christopher, Rasedee, Abdullah, Hashim, Najihah Mohd, Abdul, Ahmad Bustamam, Kadir, Arifah, Yeap, Swee Keong, Waziri, Peter, Malami, Ibrahim, Lim, Kian Lam, Etti, Christopher J
Formato: Artigo
Idioma:Inglês
Publicado em: Dove Medical Press 2017
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5367776/
https://ncbi.nlm.nih.gov/pubmed/28356713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S124324
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