FUSION-Guided Hypothesis Development Leads to the Identification of N(6),N(6)-Dimethyladenosine, a Marine-Derived AKT Pathway Inhibitor

Chemicals found in nature have evolved over geological time scales to productively interact with biological molecules, and thus represent an effective resource for pharmaceutical development. Marine-derived bacteria are rich sources of chemically diverse, bioactive secondary metabolites, but harness...

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Veröffentlicht in:Mar Drugs
Hauptverfasser: Vaden, Rachel M., Oswald, Nathaniel W., Potts, Malia B., MacMillan, John B., White, Michael A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5367032/
https://ncbi.nlm.nih.gov/pubmed/28294973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/md15030075
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