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Successful synthesis of active human coagulation factor VII by co-expression of mammalian gamma-glutamyl carboxylase and modification of vit.K cycle in Drosophila Schneider S2 cells

Mammalian gamma-glutamyl carboxylase and reduced vitamin K are indispensable for synthesis of mature mammalian vitamin K dependent proteins including some of blood coagulation factors (factors II, VII, IX, and X). It was well known that Drosophila melanogaster expressed gamma-glutamyl carboxylase an...

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Bibliografiske detaljer
Udgivet i:Cytotechnology
Main Authors: Nagahashi, Kotomi, Umemura, Kazuo, Kanayama, Naohiro, Iwaki, Takayuki
Format: Artigo
Sprog:Inglês
Udgivet: Springer Netherlands 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5366968/
https://ncbi.nlm.nih.gov/pubmed/28070807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10616-016-0059-y
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