Time- and dose dependent actions of cardiotonic steroids on transcriptome and intracellular content of Na(+) and K(+): a comparative analysis

Recent studies demonstrated that in addition to Na(+),K(+)-ATPase inhibition cardiotonic steroids (CTSs) affect diverse intracellular signaling pathways. This study examines the relative impact of [Na(+)](i)/[K(+)](i)-mediated and -independent signaling in transcriptomic changes triggered by the end...

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Bibliographic Details
Published in:Sci Rep
Main Authors: Klimanova, Elizaveta A., Tverskoi, Artem M., Koltsova, Svetlana V., Sidorenko, Svetlana V., Lopina, Olga D., Tremblay, Johanne, Hamet, Pavel, Kapilevich, Leonid V., Orlov, Sergei N.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2017
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5366943/
https://ncbi.nlm.nih.gov/pubmed/28345607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep45403
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