Inactivation of the β(1,2)-xylosyltransferase and the α(1,3)-fucosyltransferase genes in Nicotiana tabacum BY-2 Cells by a Multiplex CRISPR/Cas9 Strategy Results in Glycoproteins without Plant-Specific Glycans

Plants or plant cells can be used to produce pharmacological glycoproteins such as antibodies or vaccines. However these proteins carry N-glycans with plant-typical residues [β(1,2)-xylose and core α(1,3)-fucose], which can greatly impact the immunogenicity, allergenicity, or activity of the protein...

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Bibliographic Details
Published in:Front Plant Sci
Main Authors: Mercx, Sébastien, Smargiasso, Nicolas, Chaumont, François, De Pauw, Edwin, Boutry, Marc, Navarre, Catherine
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2017
Subjects:
Plant Science
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5366340/
https://ncbi.nlm.nih.gov/pubmed/28396675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fpls.2017.00403
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