Influence of rhlR and lasR on Polymyxin Pharmacodynamics in Pseudomonas aeruginosa and Implications for Quorum Sensing Inhibition with Azithromycin

The impact of quorum sensing on polymyxin and azithromycin pharmacodynamics was assessed in Pseudomonas aeruginosa PAO1 and an isogenic rhlR/lasR double knockout. For polymyxin B, greater killing against the rhlR/lasR knockout than against PAO1 was observed at 10(8) CFU/ml (polymyxin B half-maximal...

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Gepubliceerd in:Antimicrob Agents Chemother
Hoofdauteurs: Bulman, Zackery P., Ly, Neang S., Lenhard, Justin R., Holden, Patricia N., Bulitta, Jürgen B., Tsuji, Brian T.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Microbiology 2017
Onderwerpen:
Pharmacology
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5365695/
https://ncbi.nlm.nih.gov/pubmed/28096154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00096-16
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