Influence of rhlR and lasR on Polymyxin Pharmacodynamics in Pseudomonas aeruginosa and Implications for Quorum Sensing Inhibition with Azithromycin

The impact of quorum sensing on polymyxin and azithromycin pharmacodynamics was assessed in Pseudomonas aeruginosa PAO1 and an isogenic rhlR/lasR double knockout. For polymyxin B, greater killing against the rhlR/lasR knockout than against PAO1 was observed at 10(8) CFU/ml (polymyxin B half-maximal...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Antimicrob Agents Chemother
Egile Nagusiak: Bulman, Zackery P., Ly, Neang S., Lenhard, Justin R., Holden, Patricia N., Bulitta, Jürgen B., Tsuji, Brian T.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Microbiology 2017
Gaiak:
Pharmacology
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5365695/
https://ncbi.nlm.nih.gov/pubmed/28096154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00096-16
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