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Biophysical assay for tethered signaling reactions reveals tether-controlled activity for the phosphatase SHP-1
Tethered enzymatic reactions are ubiquitous in signaling networks but are poorly understood. A previously unreported mathematical analysis is established for tethered signaling reactions in surface plasmon resonance (SPR). Applying the method to the phosphatase SHP-1 interacting with a phosphorylate...
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| Publicado en: | Sci Adv |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
American Association for the Advancement of Science
2017
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5365251/ https://ncbi.nlm.nih.gov/pubmed/28378014 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.1601692 |
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