Biophysical assay for tethered signaling reactions reveals tether-controlled activity for the phosphatase SHP-1

Tethered enzymatic reactions are ubiquitous in signaling networks but are poorly understood. A previously unreported mathematical analysis is established for tethered signaling reactions in surface plasmon resonance (SPR). Applying the method to the phosphatase SHP-1 interacting with a phosphorylate...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Sci Adv
Hauptverfasser: Goyette, Jesse, Salas, Citlali Solis, Coker-Gordon, Nicola, Bridge, Marcus, Isaacson, Samuel A., Allard, Jun, Dushek, Omer
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Association for the Advancement of Science 2017
Schlagworte:
Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5365251/
https://ncbi.nlm.nih.gov/pubmed/28378014
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.1601692
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge