Biophysical assay for tethered signaling reactions reveals tether-controlled activity for the phosphatase SHP-1

Tethered enzymatic reactions are ubiquitous in signaling networks but are poorly understood. A previously unreported mathematical analysis is established for tethered signaling reactions in surface plasmon resonance (SPR). Applying the method to the phosphatase SHP-1 interacting with a phosphorylate...

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Detalles Bibliográficos
Publicado en:Sci Adv
Main Authors: Goyette, Jesse, Salas, Citlali Solis, Coker-Gordon, Nicola, Bridge, Marcus, Isaacson, Samuel A., Allard, Jun, Dushek, Omer
Formato: Artigo
Idioma:Inglês
Publicado: American Association for the Advancement of Science 2017
Assuntos:
Research Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5365251/
https://ncbi.nlm.nih.gov/pubmed/28378014
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.1601692
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